5 Simple Statements About phenobarbital meaning Explained
5 Simple Statements About phenobarbital meaning Explained
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five. Phenytoin, sodium valproate, valproic acid: The effect of phenobarbital around the metabolism of phenytoin seems being variable. Some investigators report an accelerating effect, while others report no effect. As the effect of phenobarbital to the metabolism of phenytoin is just not predictable, phenytoin and phenobarbital blood levels needs to be monitored more commonly if these drugs are given concurrently.
Contraindicated (1)phenobarbital will lessen the level or effect of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females mustn't decide on estradiol valerate/dienogest as their contraceptive when making use of strong CYP3A4 inducers on account of potential lessen in contraceptive efficacy.
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Phenobarbital Induction: The induction of enzymes by phenobarbital may possibly vary in fee and extent between cynomolgus monkeys and humans, which can influence drug metabolism as well as the prediction of in vivo human responses.
رانيا سليم الجهاز الهضمي والكبد د. ارقم حسن طب الاسرة د. اشرف المومني باطنية عرض كافة الأطباء
ما هي استخدامات فينوباربيتال؟ يستخدم العلاج في: علاج الصرع الكبير (نوبات الصرع التوترية الرمعية) علاج حالة الصرع المستمر كمخدر (مركن) أو كمهدئ
Contraindicated (one)phenobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration with powerful CYP3A4 inducers; these drugs lessen exposure to vandetanib by approximately 40%.
Monitor Carefully (one)ferric maltol, phenobarbital. Either increases levels of your other by unspecified interaction mechanism. Modify Therapy/Monitor Carefully. Coadministration of ferric maltol with sure oral medications might minimize the bioavailability of either ferric maltol plus some oral drugs.
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sage decreases effects of phenobarbital by pharmacodynamic antagonism. Minimal/Importance Mysterious. Theoretical interaction; some species of sage may possibly result in convulsions.
Some nations have in depth encounter managing alcohol withdrawal with phenobarbital monotherapy. Available proof supports the safety and efficacy of the strategy.
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